Thursday, March 28, 2013

Gut-Microbe Swap Helps with Weight Loss

A bacterial transplant in mice has been shown to provide some of the benefits of gastric bypass surgery without putting the animals under the knife


gut microbe, gastric bypass Here the taxonomy of gut bacteria in mice that have received gastric bypass (red) is compared to that of mice kept at the same weight (blue) and of others that were not kept on a diet (green). Image: Science Translational Medicine/AAAS

Obese people considering gastric bypass surgery to help trim their fat might one day have another option: swallowing a new supply of gut bacteria. A study in mice suggests that weight loss after bypass surgery is caused not by the operation itself, but at least in part by a change in the amounts of various species of microbes in the gut.

A bypass operation separates off a small part of the stomach and connects that directly to the intestines. Recipients tend to feel less hungry, fill up more quickly and burn more calories at rest, and they often lose up to 75% of their excess fat. Counter-intuitively, this is thought to be caused by a change in metabolism, rather than by the reduced size of the stomach.

Gut microbes are thought to be part of this picture. People who have had bypasses are known to experience changes in the selection of microbes in their guts. Fat people have been shown to host a different selection of gut bacteria from people who are obese, and transferring the gut bacteria of fat mice into thin ones can cause the thin mice to pack on extra weight. But no one knew whether the microbes in bypass patients changed because they got thin, or if the patients got thin because the microbes changed.

Chop and change
To investigate, Lee Kaplan, director of the Obesity, Metabolism and Nutrition Institute at Massachusetts General Hospital in Boston, and his colleagues gave about a dozen obese mice bypass surgery. As expected, the mice lost about 29% of their body weight, and kept it off despite a high-fat diet. New conditions in their bodies ? such as a change in bile acids ? allowed a different set of gut bacteria to thrive.

The researchers then took faecal samples from the mice that had been operated on, and put bacteria from them into the guts of mice specially bred without any gut flora. These mice, which were not obese, lost 5% of their weight without any changes to their diet. The results are reported in Science Translational Medicine.

The effect is impressively large, says Randy Seeley, an obesity researcher at the University of Cincinnati in Ohio, particularly given that sterile mice almost always gain weight when given any kind of gut flora. The fact that the mice getting the second-hand bacteria did not lose as much weight as those that had surgery suggests that other factors are also at work; these could include hormonal changes.

The results are promising for obesity treatments, but there are still hurdles to overcome. ?You can?t just take a pill of the right bacteria and have them stick around,? says Seeley. If the gut?s environmental conditions don?t change, then the original microbes come back, he says. Kaplan says that the next steps are to isolate the four bacteria types that the study found to be at play and introduce them into obese mice or people. Antibiotic treatments might help the new bacteria to stick. ?I believe it?s possible,? says Kaplan.

This article is reproduced with permission from the magazine Nature. The article was first published on March 27, 2013.

Source: http://rss.sciam.com/click.phdo?i=fca6fa7a6f995e1106279c0f34dc1c43

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Eggs-treme: Christie's auctions super-sized egg

LONDON (AP) ? It's a foot long, nearly nine inches in diameter, and would once have made a really, really, big omelet.

A London auction house is hoping buyers will be scrambling to take a crack at this natural wonder, a massive fossilized egg laid long ago on the island of Madagascar by a now-extinct elephant bird.

Christie's said Wednesday that the oversized ovum ? laid sometime before elephant birds were wiped out several hundred years ago ? is expected to sell for up to 30,000 pounds (roughly $45,000).

Flightless, fruit-gobbling elephant birds resembled giant ostriches and could grow to be 11 feet high (3.4 meters). Christie's says their eggs are 100 times the size of an average chicken's.

The egg is being sold during a travel and science sale on April 24.

Source: http://news.yahoo.com/eggs-treme-christies-auctions-super-sized-egg-133424322.html

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Boxee TV update brings DLNA access, on device DVR management and more

Boxee TV update brings DLNA access, on device DVR management and more

Boxee's second box is getting a fresh round of updates, as GigaOm points out software version 2.1.0.7781 has been detailed and is rolling out. It includes features that appeal to classic Boxee fans like support for DLNA rendering that lets it browse and play files from PCs or other devices on the same network and DMR that lets users push media to it from apps like Skifta. For more traditional viewers, the update also brings a standard TV guide users can pull up by selecting "TV" on the home screen, the ability to schedule and manage DVR recordings from antenna on the box itself (previously only possible via webpage for the still-in-beta feature), notifications for upcoming recordings and even 3D support in the Vudu app. Boxee co-founder Idan Cohen joined us at Expand and mentioned some of the other updates the team is working on, we'll see if oft-requested features like the ability to pause live TV are added any time soon. Hit the source link for the full list of changes, current owners should see the new software arrive over the next few days.

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Via: GigaOm

Source: Boxee Support

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/ZXw7NDmK7Gw/

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Wednesday, March 27, 2013

State and Local Public Finance: The Future of the Wheelage Tax


The wheelage tax is a $5 user fee/tax on most vehicles kept in a metropolitan county and is levied by the respective metropolitan county board of commissioners.?The Minnesota's?statute?that covers the wheelage tax, specifies that the revenue generated by the wheelage tax must go directly to the county?s road and bridge fund.?

As of December 2012, only the metropolitan counties had the authority to levy such a tax. The seven counties are listed below:

1. Anoka County

2. Carver County

3. Dakota County

4. Scott County

5. Washington County

6. Hennepin County

7. Ramsey County

While the metropolitan counties have the authority to levy the tax, Hennepin and Ramsey County have not imposed this tax on its residents.?In fact in 2011, the Hennepin County Board rejected?the proposition of levying the tax to raise revenue to defray the costs of building the Lowry Avenue Bridge.?Board Chairman Mike Opat said he did not support the wheelage tax because it is a regressive tax that could potentially make the poor even poorer. In this legislative session?H.F 709?and?S.F 583 want to broaden the county wheelage tax authority to all of Minnesota?s 87 counties. Additionally, they seek to eliminate the $5 cap and set a new $20 cap on this tax, beginning in 2014. Supporters of the bills, in a Star Tribune?article, pointed out that Minnesota counties are struggling in keeping up with the road and bridge maintenance costs and increasing and broadening the wheelage tax will allow all counties to generate revenue to pay for these maintenance costs. While local governments have other revenue raising options, the wheel tax is said to be more politically palatable because its funds are collected from the users and these funds stay in the county for county projects, as opposed to other taxes like a state wide gas tax, whose funds do not stay entirely in the county.? As of March 22, 2013, both the House and Senate bills have cleared their respective policy committees and will now be examined in both the Senate and House tax committees. For now, we will have to wait and see if they become law.??? Interestingly, while researching the wheelage tax, I came across a wheelage tax?blog from Jason B, a 2010 State and Local Public Finance student. In his blog, Jason foresaw that the local government aid (LGA) reductions faced by county governments would push the metropolitan counties to raise the wheelage tax from its $5 capped amount.?In our legislative session, Jason?s recommendation is certainly a possibility, and in fact if the bills are passed, they could have even greater impacts since now not only will there be an increase in the fee but also an expansion to all counties.?

Source: http://pa5113.blogspot.com/2013/03/the-future-of-wheelage-tax.html

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Password Genie 4.0


Installing antivirus and firewall utilities will keep your PC safe, but installing a password manager may be even more important. Without the aid of a password manager, you'll probably use the same weak passwords over and over, simply because you can remember them. That can put your email account, your social media account, or even your bank account at risk. Password Genie 4.0 ($15 per year direct) handles all expected password management tasks; this new version adds the ability to fill personal data in Web forms.

At $15 per year, Password Genie barely costs more than LastPass 2.0 Premium (which runs $12 per year). You can install the product on up to five PCs or Macs and sync your stored data between those. The free Android edition will also sync with your PC-based accounts, as will an iOS edition that's in the works now.

Getting Started
As with LastPass 2.0, Dashlane 1.1, and almost all other password managers, you define a strong master password during the installation process. This password protects all of your other passwords, so it really needs to be something that you can remember but that nobody else would guess.

The master password field turns green when you've achieved a minimal strength level. That's decent, but others offer more help. Dashlane's master password wizard leads you through the process of creating a password that's both strong and memorable, a process similar to PCMag's own recommended technique. Norton Identity Safe displays a sliding scale of password strength, with specific advice on how to reach a higher level.

During installation you can choose to import any passwords you've saved in Chrome, Firefox, Internet Explorer, or Safari. (The fact that Password Genie can import these may clue you in to the fact that browser-stored passwords aren't all that secure.) New in this version, you can choose to import those passwords even after the initial installation.

Password Capture
Like LastPass, Password Genie integrates with the browser by installing a single, simple button. The button clearly visible in Firefox; in some versions of Internet Explorer, you may find it pushed out of view until you click the >> button at the far end of the browser toolbar.

When you log in to a secure site, Password Genie offers to save your credentials. Like LastPass, it lets you identify a new or existing folder to categorize the site you're saving. By default, it names the saved site using the URL, but you can change that name to whatever will be most memorable. Password Genie uses a popup dialog box to gather this information; LastPass and Identity Safe have switched to a less obtrusive infobar that slides in from the top of the browser window.

In testing, Password Genie correctly captured almost all of the sites I tried. One oddball site uses two password fields; I couldn't get that one into Password Genie even by editing with the Advanced Form. With its "Save All Entered Data" feature, LastPass is among the few that handle this particular page.

If you log in to a known site using different credentials, Password Genie offers two choices: save a new login or replace the existing one. It detects password change events very nicely, and also detects when you're creating a new account. By default it will pop up with a suggested strong password for that new account. You can also launch its password generator manually.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/vez1A91RuC8/0,2817,2417011,00.asp

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Tuesday, March 26, 2013

Moon and asteroids share history, NASA scientists find

Mar. 25, 2013 ? NASA and international researchers have discovered that Earth's moon has more in common than previously thought with large asteroids roaming our solar system.

Scientists from NASA's Lunar Science Institute (NLSI) in Moffett Field, Calif., discovered that the same population of high-speed projectiles that impacted our lunar neighbor four billion years ago, also hit the giant asteroid Vesta and perhaps other large asteroids.

The research unveils an unexpected link between Vesta and the moon, and provides new means for studying the early bombardment history of terrestrial planets. The findings are published in the March issue of Nature Geoscience.

"It's always intriguing when interdisciplinary research changes the way we understand the history of our solar system," said Yvonne Pendleton, NLSI director. "Although the moon is located far from Vesta, which is in the main asteroid belt between the orbits of Mars and Jupiter, they seem to share some of the same bombardment history."

The findings support the theory that the repositioning of gas giant planets like Jupiter and Saturn from their original orbits to their current location destabilized portions of the asteroid belt and triggered a solar system-wide bombardment of asteroids billions of years ago, called the lunar cataclysm.

The research provides new constraints on the start and duration of the lunar cataclysm, and demonstrates that the cataclysm was an event that affected not only the inner solar system planets, but the asteroid belt as well.

The moon rocks brought back by NASA Apollo astronauts have long been used to study the bombardment history of the moon. Now the ages derived from meteorite samples have been used to study the collisional history of main belt asteroids. In particular, howardite and eucrite meteorites, which are common species found on Earth, have been used to study asteroid Vesta, their parent body. With the aid of computer simulations, researchers determined that meteorites from Vesta recorded high-speed impacts which are now long gone.

Researchers have linked these two datasets and found that the same population of projectiles responsible for making craters and basins on the moon were also hitting Vesta at very high velocities, enough to leave behind a number of telltale, impact-related ages.

The team's interpretation of the howardites and eucrites was augmented by recent close-in observations of Vesta's surface by NASA's Dawn spacecraft. In addition, the team used the latest dynamical models of early main belt evolution to discover the likely source of these high velocity impactors. The team determined that the population of projectiles that hit Vesta had orbits that also enabled some objects to strike the moon at high speeds.

"It appears that the asteroidal meteorites show signs of the asteroid belt losing a lot of mass four billion years ago, with the escaped mass beating up on both the surviving main belt asteroids and the moon at high speeds" says lead author Simone Marchi, who has a joint appointment between two of NASA's Lunar Science Institutes, one at the Southwest Research Institute in Boulder, Colo., and another at the Lunar and Planetary Institute in Houston. "Our research not only supports the current theory, but it takes it to the next level of understanding."

The NLSI is headquartered at NASA Ames Research Center, Moffett Field, Calif. The Dawn mission to Vesta and Ceres is managed by NASA's Jet Propulsion Laboratory, Pasadena, Calif., for NASA's Science Mission Directorate, Washington. Dawn is a project of the directorate's Discovery Program, managed by NASA's Marshall Space Flight Center in Huntsville, Ala.

To learn more about NLSI, visit: http://lunarscience.nasa.gov .

For more information about the Dawn mission, visit: www.nasa.gov/dawn .

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The above story is reprinted from materials provided by NASA/Jet Propulsion Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. Marchi, W. F. Bottke, B. A. Cohen, K. W?nnemann, D. A. Kring, H. Y. McSween, M. C. De Sanctis, D. P. O?Brien, P. Schenk, C. A. Raymond, C. T. Russell. High-velocity collisions from the lunar cataclysm recorded in asteroidal meteorites. Nature Geoscience, 2013; DOI: 10.1038/ngeo1769

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/tTc-NiRYgpQ/130325185237.htm

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Early number sense plays role in later math skills

This image provided by the University of Missouri shows an illustration part of a University of Missouri study that examined first-graders? "number system knowledge." That?s how well they understand such things as that numbers represent quantities. Youngsters who didn?t have a good grasp of these concepts went on have lower scores on a key math skills test years later when they were in seventh grade. We know a lot about how babies learn to talk, and youngsters learn to read. Now scientists are unraveling the earliest building blocks of math _ and what children know about numbers as they begin first grade seems to play a big role in how well they do everyday calculations later on. (AP Photo/University of Missouri)

This image provided by the University of Missouri shows an illustration part of a University of Missouri study that examined first-graders? "number system knowledge." That?s how well they understand such things as that numbers represent quantities. Youngsters who didn?t have a good grasp of these concepts went on have lower scores on a key math skills test years later when they were in seventh grade. We know a lot about how babies learn to talk, and youngsters learn to read. Now scientists are unraveling the earliest building blocks of math _ and what children know about numbers as they begin first grade seems to play a big role in how well they do everyday calculations later on. (AP Photo/University of Missouri)

(AP) ? We know a lot about how babies learn to talk, and youngsters learn to read. Now scientists are unraveling the earliest building blocks of math ? and what children know about numbers as they begin first grade seems to play a big role in how well they do everyday calculations later on.

The findings have specialists considering steps that parents might take to spur math abilities, just like they do to try to raise a good reader.

This isn't only about trying to improve the nation's math scores and attract kids to become engineers. It's far more basic.

Consider: How rapidly can you calculate a tip? Do the fractions to double a recipe? Know how many quarters and dimes the cashier should hand back as your change?

About 1 in 5 adults in the U.S. lacks the math competence expected of a middle-schooler, meaning they have trouble with those ordinary tasks and aren't qualified for many of today's jobs.

"It's not just, can you do well in school? It's how well can you do in your life," says Dr. Kathy Mann Koepke of the National Institutes of Health, which is funding much of this research into math cognition. "We are in the midst of math all the time."

A new study shows trouble can start early.

University of Missouri researchers tested 180 seventh-graders. Those who lagged behind their peers in a test of core math skills needed to function as adults were the same kids who'd had the least number sense or fluency way back when they started first grade.

"The gap they started with, they don't close it," says Dr. David Geary, a cognitive psychologist who leads the study that is tracking children from kindergarten to high school in the Columbia, Mo., school system. "They're not catching up" to the kids who started ahead.

If first grade sounds pretty young to be predicting math ability, well, no one expects tots to be scribbling sums. But this number sense, or what Geary more precisely terms "number system knowledge," turns out to be a fundamental skill that students continually build on, much more than the simple ability to count.

What's involved? Understanding that numbers represent different quantities ? that three dots is the same as the numeral "3'' or the word "three." Grasping magnitude ? that 23 is bigger than 17. Getting the concept that numbers can be broken into parts ? that 5 is the same as 2 and 3, or 4 and 1. Showing on a number line that the difference between 10 and 12 is the same as the difference between 20 and 22.

Factors such as IQ and attention span didn't explain why some first-graders did better than others. Now Geary is studying if something that youngsters learn in preschool offers an advantage.

There's other evidence that math matters early in life. Numerous studies with young babies and a variety of animals show that a related ability ? to estimate numbers without counting ? is intuitive, sort of hard-wired in the brain, says Mann Koepke, of NIH's National Institute of Child Health and Human Development. That's the ability that lets you choose the shortest grocery check-out line at a glance, or that guides a bird to the bush with the most berries.

Number system knowledge is more sophisticated, and the Missouri study shows children who start elementary school without those concepts "seem to struggle enormously," says Mann Koepke, who wasn't part of that research.

While schools tend to focus on math problems around third grade, and math learning disabilities often are diagnosed by fifth grade, the new findings suggest "the need to intervene is much earlier than we ever used to think," she adds.

Exactly how to intervene still is being studied, sure to be a topic when NIH brings experts together this spring to assess what's known about math cognition.

But Geary sees a strong parallel with reading. Scientists have long known that preschoolers who know the names of letters and can better distinguish what sounds those letters make go on to read more easily. So parents today are advised to read to their children from birth, and many youngsters' books use rhyming to focus on sounds.

Likewise for math, "kids need to know number words" early on, he says.

NIH's Mann Koepke agrees, and offers some tips:

?Don't teach your toddler to count solely by reciting numbers. Attach numbers to a noun ? "Here are five crayons: One crayon, two crayons..." or say "I need to buy two yogurts" as you pick them from the store shelf ? so they'll absorb the quantity concept.

?Talk about distance: How many steps to your ball? The swing is farther away; it takes more steps.

?Describe shapes: The ellipse is round like a circle but flatter.

?As they grow, show children how math is part of daily life, as you make change, or measure ingredients, or decide how soon to leave for a destination 10 miles away,

"We should be talking to our children about magnitude, numbers, distance, shapes as soon as they're born," she contends. "More than likely, this is a positive influence on their brain function."

___

EDITOR'S NOTE ? Lauran Neergaard covers health and medical issues for The Associated Press in Washington.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-03-26-HealthBeat-Math%20Skills/id-23fea68cbf434ed18f266f21fc4f16c5

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